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Brefeldin A

CAS No. : 20350-15-6

MCE 國(guó)際站：Brefeldin A

產(chǎn)品活性：Brefeldin A (BFA) 是一種內(nèi)酯抗生素，是蛋白質(zhì)運(yùn)輸?shù)奶囟ㄒ种苿?。Brefeldin A 阻斷分泌蛋白和膜蛋白從內(nèi)質(zhì)網(wǎng)向高爾基體的轉(zhuǎn)運(yùn),。Brefeldin A 也是一種自噬 (autophagy) 和 mitophagy 抑制劑。Brefeldin A 可抑制 HSV-1病毒,，并具有抗癌活性,。

研究領(lǐng)域：Autophagy  |  Cell Cycle/DNA Damage  |  Anti-infection

作用靶點(diǎn)：Autophagy  |  CRISPR/Cas9  |  Mitophagy  |  HSV  |  Antibiotic  |  Bacterial

In Vitro: Brefeldin A (BFA) treatment for 15 h or 40 h, causes dramatic swelling of the Endoplasmic Reticulum (ER) and shifts its localization to the periphery of normal rat kidney (NRK) cells. Prolonged Brefeldin A treatment results in marked disruption of the MT and actin cytoskeleton. ADP-ribosylation of BARS is mediated by formation of a conjugate between Brefeldin A and ADPR. BARS shows BAC binding when incubated with the medium from the BFA-treated CD38⁺ HeLa cells. Brefeldin A induces anchorage-independent cell death in MDA-MB-231 breast cancer cells, inhibits the formation of MDA-MB-231 colonies in 3D and 2D cultures and inhibits the migration and MMP 9 (Matrix Metallopeptidase 9) activity of MDA-MB-231.

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